GeneID: 31

Description:
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor (PGF), and plays an important role in angiogenesis and vasculogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Polymorphisms in this gene were found to be strongly associated with the HbF response to hydroxyurea (HU) in sickle cell patients.

Synonyms: FLT , fms-related tyrosine kinase 1 , vascular endothelial growth factor receptor 1 , VEGFR1

Comments:
N/A

Number of entries/variants: 13

1. Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M, Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family., Oncogene , 5(4), 519-24, 1990 PubMed
2. Herley MT, Yu Y, Whitney RG, Sato JD, Characterization of the VEGF binding site on the Flt-1 receptor., Biochem. Biophys. Res. Commun. , 262(3), 731-8, 1999 PubMed
3. Ma Q, Wyszynski DF, Farrell JJ, Kutlar A, Farrer LA, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea., Pharmacogenomics J. , 7(6), 386-94, 2007 PubMed
4. Sela S, Itin A, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Yagel S, Keshet E, A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia., Circ. Res. , 102(12), 1566-74, 2008 PubMed