GeneID: 316
Names
| Common Name: | CYP3A4 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 7 (NC_000007.14) | Locus: | NG_008421.1 (CYP3A4) |
| HUGO Symbol: | CYP3A4 | Full Name: | cytochrome P450 family 3 subfamily A member 4 |
| Exons: | 13 | Introns: | 12 |
Description:
CYP3A4 is a member of the cytochrome P450 (CYP) superfamily of monooxygenases that catalyze the metabolism of various endogenous and exogenous substrates, including xenobiotics, steroids, and fatty acids. CYP3A4 is the most abundant enzyme of CYPs in the liver, metabolizing more than 50% of the clinically used drugs. Genetic variance in CYP3A4 gene associated with episodes of pain in patients with sickle cell disease.
Synonyms: CYP3A , NF-25 , CYP3A3 , P450C3 , CYPIIIA3 , CYPIIIA4
Comments:
N/A
Number of entries/variants: 1
Sequence Viewer
Publications / Origin
- Zhou SF, Xue CC, Yu XQ, Li C, Wang G, Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring., Ther Drug Monit, 29(6), 687-710, 2007 PubMed
- Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
| A/A | Date | Curator(s) | Comments |
|---|---|---|---|
| 1 | 2019-11-27 12:33:57 | The IthaGenes Curation Team | Created |