GeneID: 342


Common Name: HSF1 Type: Gene
Chromosome: 8 (NC_000008.11) Locus: NM_005526.4 (HSF1)
HUGO Symbol: HSF1 Full Name: heat shock transcription factor 1
Exons: 13 Introns: 12

The product of the HSF1 gene functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, also called heat shock proteins (HSPs), which assist in refolding or degrading injured intracellular proteins. HSF1 is recognized as a putative regulator of fetal γ-globin gene expression during eryrthroid differentiation. Mechanistically, HSF1 binds to the LCR HS3 region via its canonical binding motif (TTCnnGAAnnTTC), indicating that this gene is involved in LCR-mediated long-range regulation of γ-globin and β-globin genes during erythropoiesis.

Synonyms: HSTF1


Sequence Viewer

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Publications / Origin

  1. Barna J, Csermely P, Vellai T, Roles of heat shock factor 1 beyond the heat shock response., Cell. Mol. Life Sci., 75(16), 2897-2916, 2018 PubMed
  2. Gao J, Liu J, Zhang L, Zhang Y, Guo Q, Li Y, Tong J, Wang H, Zhou J, Zhu F, Shi L, Zhao H, Heat shock transcription factor 1 regulates the fetal γ- and adult β-globin expression in a stress-dependent and independent manner during erythroid differentiation., Exp. Cell Res., 2019 PubMed
Created on 2020-01-02 12:30:49, Last reviewed on (Show full history)

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