GeneID: 385
Names
Common Name: | CREB1 | Type: | Gene |
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Chromosome: | 2 (NC_000002.12) | Locus: | NG_023299.1 (CREB1) |
HUGO Symbol: | CREB1 | Full Name: | Cyclic AMP-responsive element-binding protein 1 |
Exons: | 8 | Introns: | 7 |
Description:
The CREB1 gene encodes a transcription factor that belongs to the family of leucine zipper proteins (bZIP). The basic leucine zipper motif allows for dimerization and sequence-specific DNA-binding interactions. A series of knockdown experiments in erythroid cell lines and primary erythroid progenitors supported a role for CREB1 signaling in Gγ-globin gene transcription. CREB1 and its binding partner CREB binding protein (CBP) [GeneID: 386] co-localize at the Gγ-globin cAMP response element (G-CRE) located between -1222 and -1229 relative to the cap site to induce γ-globin expression through a p38 mitogen-activated protein kinase-dependent mechanism. Genetic variation in the G-CRE region associated with foetal haemoglobin (HbF) levels in sickle cell disease.
Synonyms: CREB , CREB-1
Comments:
N/A
Number of entries/variants: 0
Sequence Viewer
Publications / Origin
- Ramakrishnan V, Pace BS, Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway., Blood Cells Mol. Dis., 47(1), 12-22, 2011 PubMed
- Liu L, Pertsemlidis A, Ding LH, Story MD, Steinberg MH, Sebastiani P, Hoppe C, Ballas SK, Pace BS, A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease., Exp. Biol. Med. (Maywood) , 2016 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2020-09-18 10:35:07 | The IthaGenes Curation Team | Created |
2 | 2020-09-18 10:57:21 | The IthaGenes Curation Team | Reviewed. Reference added. |