GeneID: 390


Common Name: MCC Type: Gene
Chromosome: 5 (NC_000005.10) Locus: NG_012265.1 (MCC)
HUGO Symbol: MCC Full Name: MCC regulator of WNT signaling pathway
Exons: 19 Introns: 18

The MCC gene is a candidate for the putative colorectal tumor suppressor gene located at 5q21. The N-terminal domain of MCC is required for repressing the Wnt/β-catenin signaling pathway in colorectal cancer cells. Genetic variance in MCC associated with F-cell levels in sickle cell disease.

Synonyms: MCC1


Number of entries/variants: 1


Sequence Viewer

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Publications / Origin

  1. Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR, Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients., J. Hum. Genet. , 56(4), 316-23, 2011 PubMed
Created on 2020-10-05 15:50:16, Last reviewed on 2020-10-05 15:51:05 (Show full history)

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