GeneID: 398


Common Name: MAP2K5 Type: Gene
Chromosome: 15 (NC_000015.10) Locus: NG_029143.1 (MAP2K5)
HUGO Symbol: MAP2K5 Full Name: mitogen-activated protein kinase kinase 5
Exons: 22 Introns: 21

MAP2K5 is a member of the mitogen-activated kinase kinase (MAPKK) family, which forms part of a three-tiered core-signalling module (MAP3K→MAP2K→MAPK), a common mechanism of signal transduction to different MAPK pathways. MAP2K5 specifically interacts with and activates MAPK7/ERK5. MAP2K5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Genetic variance in MAP2K5 associated with F-cell levels in sickle cell disease.

Synonyms: MEK5 , MAPKK5 , PRKMK5 , HsT17454


Sequence Viewer

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Publications / Origin

  1. Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR, Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients., J. Hum. Genet. , 56(4), 316-23, 2011 PubMed
Created on 2020-10-06 14:56:03, Last reviewed on (Show full history)

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