GeneID: 404


Common Name: CAT Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NG_013339.2 (CAT)
HUGO Symbol: CAT Full Name: catalase
Exons: 13 Introns: 12

The CAT gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Oxidative stress plays a role in the development of many chronic or late-onset diseases, including thalassaemia. Genetic variance in CAT associated with improved hydroxyurea (HU) response in patients with sickle cell disease based on improvement in infammatory markers measured. A lower catalase expression and activity may lead to higher HU bioavailability.

Synonyms: N/A


Number of entries/variants: 2


Sequence Viewer

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Publications / Origin

  1. Yahouédéhou SCMA, Neres JSDS, da Guarda CC, Carvalho SP, Santiago RP, Figueiredo CVB, Fiuza LM, Ndidi US, de Oliveira RM, Fonseca CA, Nascimento VML, Rocha LC, Adanho CSA, da Rocha TSC, Adorno EV, Goncalves MS, Sickle Cell Anemia: Variants in the , , and Genes Are Associated With Improved Hydroxyurea Response., Front Pharmacol, 11(0), 553064, 2020 PubMed
Created on 2020-10-13 12:23:32, Last reviewed on (Show full history)

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