GeneID: 407

Names

Common Name:	MED27	Type:	Gene
Chromosome:	9 (NC_000009.12)	Locus:	NM_004269.4 (MED27)
HUGO Symbol:	MED27	Full Name:	mediator complex subunit 27
Exons:	8	Introns:	7

Description:
The MED27 gene encodes a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Genetic variance in MED27 associated with F-cell levels in sickle cell anaemia.

Synonyms: MED3 , CRSP8 , CRAP34 , CRSP34 , TRAP37

Comments:
N/A

Number of entries/variants: 1

External Links

NCBI Gene	UniProtKB
HGNC	OMIM

IthaScore

Sequence Viewer

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Publications / Origin

Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR, Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients., J. Hum. Genet. , 56(4), 316-23, 2011 PubMed

Created on 2020-10-15 12:30:31, Last reviewed on (Show full history)

A/A	Date	Curator(s)	Comments
1	2020-10-15 12:30:31	The IthaGenes Curation Team	Created

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