GeneID: 442
Names
Common Name: | MAZ | Type: | Gene |
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Chromosome: | 16 (NC_000016.10) | Locus: | NM_002383.4 (MAZ) |
HUGO Symbol: | MAZ | Full Name: | MYC associated zinc finger protein |
Exons: | 5 | Introns: | 4 |
Description:
The Myc-associated zinc finger protein (MAZ) was identified and characterized as a regulatory protein associated with MYC gene expression. It functions as a DNA-specific transcription factor and is often found at genomic binding sites adjacent to CTCF, the chromatin architectural factor. MAZ plays a role in erythropoiesis; it binds to the promoter of the alpha-globin genes and its shRNA-mediated knowckdown impairs differentiation in primary human erythroid cells. Genome-wide mapping in primary human erythroid cells revealed that MAZ also occupies active promoters as well as GATA1-bound enhancer elements of key genes within the erythroid differentiation pathway.
Synonyms: PUR1 , ZF87 , Pur-1 , SAF-1 , SAF-2 , SAF-3 , Zif87 , ZNF801 , ,
Comments:
N/A
Number of entries/variants: 0
IthaScore
Sequence Viewer
Publications / Origin
- Xiao T, Li X, Felsenfeld G, The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization., Proc Natl Acad Sci U S A, 118(7), 0, 2021 PubMed
- Deen D, Butter F, Daniels DE, Ferrer-Vicens I, Ferguson DCJ, Holland ML, Samara V, Sloane-Stanley JA, Ayyub H, Mann M, Frayne J, Garrick D, Vernimmen D, Identification of the transcription factor MAZ as a regulator of erythropoiesis., Blood Adv, 5(15), 3002-3015, 2021 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2021-08-13 12:59:00 | The IthaGenes Curation Team | Created |