GeneID: 446

Description:
BACH1 is a member of the Cap ‘n' Collar and basic region leucine zipper family (CNC-bZip) of transcription factors that acts as a repressor or activator, depending on the context. It has a key regulatory role in the production of reactive oxygen species, cell cycle, heme homeostasis, hematopoiesis, and immunity. It forms a heterodimer with small MAF proteins to bind MAF recognition elements (MAREs) in the promoters of target genes to supress their expression, including heme-responsive genes like α- and β-globin, and oxidative stress-response genes like heme oxygenase-1 (HO-1) and NADPH quinone oxidoreductase 1 (NQO1). The reduction of heme content in β-thalassaemia red cells led to an increase in BACH1 gene expression, which positively correlated to α-, β-, and γ-globin gene expression and to HO-1 gene expression. The expression of BACH1 could be elevated as a compensatory mechanism to decrease the α/β-globin chain imbalance and to reduce the oxidative stress produced by the imbalance.

Synonyms: BACH-1 , BTBD24

Comments:
N/A

Number of entries/variants: 0

1. Lee TY, Muniandy L, Teh LK, Abdullah M, George E, Sathar J, Lai MI, Correlation of BACH1 and Hemoglobin E/Beta-Thalassemia Globin Expression., Turk J Haematol, 33(1), 15-20, 2016 PubMed
2. Zakaria NA, Islam MA, Abdullah WZ, Bahar R, Mohamed Yusoff AA, Abdul Wahab R, Shamsuddin S, Johan MF, Epigenetic Insights and Potential Modifiers as Therapeutic Targets in -Thalassemia., Biomolecules, 11(5), 0, 2021 PubMed