GeneID: 450

Names

Common Name:	SOD1	Type:	Gene
Chromosome:	21 (NC_000021.9)	Locus:	NG_008689.1 (SOD1)
HUGO Symbol:	SOD1	Full Name:	superoxide dismutase 1
Exons:	5	Introns:	4

Description:
The SOD1 gene encodes superoxide dismutase-1, a major cytoplasmic antioxidant enzyme that metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide, thus providing a defense against oxygen toxicity. Studies reported an up-regulation in gene and protein expression of SOD1 in β-thalassaemia intermedia patients compared to healthy individuals. This could result from compensatory mechanisms in response to the high levels of ROS observed in β-thalassaemia intermedia.

Synonyms: ALS , SOD , ALS1 , IPOA , STAHP , hSod1

Comments:
N/A

Number of entries/variants: 0

External Links

NCBI Gene	UniProtKB
HGNC	OMIM

IthaScore

Sequence Viewer

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Publications / Origin

Zakaria NA, Islam MA, Abdullah WZ, Bahar R, Mohamed Yusoff AA, Abdul Wahab R, Shamsuddin S, Johan MF, Epigenetic Insights and Potential Modifiers as Therapeutic Targets in -Thalassemia., Biomolecules, 11(5), 0, 2021 PubMed

Created on 2021-08-19 17:53:09, Last reviewed on (Show full history)

A/A	Date	Curator(s)	Comments
1	2021-08-19 17:53:09	The IthaGenes Curation Team	Created

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