GeneID: 450


Common Name: SOD1 Type: Gene
Chromosome: 21 (NC_000021.9) Locus: NG_008689.1 (SOD1)
HUGO Symbol: SOD1 Full Name: superoxide dismutase 1
Exons: 5 Introns: 4

The SOD1 gene encodes superoxide dismutase-1, a major cytoplasmic antioxidant enzyme that metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide, thus providing a defense against oxygen toxicity. Studies reported an up-regulation in gene and protein expression of SOD1 in β-thalassaemia intermedia patients compared to healthy individuals. This could result from compensatory mechanisms in response to the high levels of ROS observed in β-thalassaemia intermedia.

Synonyms: ALS , SOD , ALS1 , IPOA , STAHP , hSod1


Sequence Viewer

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Publications / Origin

  1. Zakaria NA, Islam MA, Abdullah WZ, Bahar R, Mohamed Yusoff AA, Abdul Wahab R, Shamsuddin S, Johan MF, Epigenetic Insights and Potential Modifiers as Therapeutic Targets in -Thalassemia., Biomolecules, 11(5), 0, 2021 PubMed
Created on 2021-08-19 17:53:09, Last reviewed on (Show full history)

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