GeneID: 454


Common Name: miR-122 Type: Gene
Chromosome: 18 (NC_000018.10) Locus: NR_029667.1 (MIR122)
HUGO Symbol: MIR122 Full Name: microRNA 122
Exons: N/A Introns: N/A

MicroRNAs (miRNAs), such as MIR122, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. MIR122 comprises nearly 70% of all hepatic miRNA expression and plays a key role in the regulation of systemic iron metabolism primarily through an effect on hepcidin levels. In fact, it directly targets and suppresses the hemochromatosis (HFE) and hemojuvelin (HJV or HFE2) genes that encode activators of hepcidin expression. Hepcidin deficiency results in the development of systemic iron overload because of excessive iron absorption. Blood transfusion was shown to affect MIR122 expression, resulting in higher levels of MIR122 in transfusion-dependent (TDT) β-thalassemia patients that were also associated with excess iron in liver and cardiac tissues. It is postulated that MIR122 could be a biomarker for cellular damage under condition of tissue iron excess.

Synonyms: MIR122A , MIRN122 , mir-122 , MIRN122A , miRNA122 , miRNA122A , hsa-mir-122


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Publications / Origin

  1. Davis M, Clarke S, Influence of microRNA on the maintenance of human iron metabolism., Nutrients, 5(7), 2611-28, 2013 PubMed
  2. El-Khazragy N, Matbouly S, Hanna DH, Mahran NA, Mostafa SA, Abdelrehim BA, Farouk YK, Abuelela S, Circulating miRNAs and tissue iron overload in transfusion-dependent β-thalassemia major: novel predictors and follow-up guide., Ann Hematol, 2021 PubMed
Created on 2021-09-20 16:47:21, Last reviewed on (Show full history)

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