GeneID: 457

Description:
MicroRNAs (miRNAs), such as MIR486-1, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. MIR486-1 is highly conserved among mammals and is located on chromosome 8p11 within the Ankyrin-1 (ANK1) gene. It encodes two mature miRNAs, miR-486-3p and miR-486-5p. Alteration of both isoforms has been linked to cancers. In the haematopoietic system, both isoforms are strongly expressed in primary adult erythroid cells. Mounting evidence suggests that miR-486-3p plays a key role in the process of erythroid differentiation and foetal haemoglobin (HbF) regulation. miR-486-3p expression correlates with increased HbF synthesis in erythroid cells of beta-thalassaemia patients. miR-486-3p directly targets BCL11A [GeneID: 15], a known HbF repressor, by binding to the extra-long isoform of BCL11A 3′UTR, thereby affecting γ-globin gene expression. Therapeutic approaches that increase the HbF concentration have great potential for ameliorating the clinical and haematologic severity of beta-thalassaemia and other beta-haemoglobinopathies.

Synonyms: MIR486 , MIRN486 , mir-486-1 , hsa-mir-486 , hsa-mir-486-1

Comments:
N/A

Number of entries/variants: 0

1. Lulli V, Romania P, Morsilli O, Cianciulli P, Gabbianelli M, Testa U, Giuliani A, Marziali G, MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A., PLoS One, 8(4), e60436, 2013 PubMed
2. Lai K, Jia S, Yu S, Luo J, He Y, Genome-wide analysis of aberrantly expressed lncRNAs and miRNAs with associated co-expression and ceRNA networks in β-thalassemia and hereditary persistence of fetal hemoglobin., Oncotarget, 8(30), 49931-49943, 2017 PubMed
3. Eltaweel NH, ElKamah GY, Khairat R, Atia HAE, Amr KS, Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia., J Genet Eng Biotechnol, 19(1), 51, 2021 PubMed