GeneID: 459

Description:
MicroRNAs (miRNAs), such as MIR16-1, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. MIR16-1 is located on chromosome 13q14.3 within DLEU2 gene, adjacent to microRNA MIR15A [GeneID: 456]; both microRNAs have identical seed sequences. MIR15A/ MIR16-1 are strongly expressed in primary adult erythroid cells and contributes to the process of erythroid differentiation. Their expression correlates with increased embryonic and foetal haemoglobin (HbF) levels in newborns in human trisomy 13 through direct inhibition of MYB [GeneID: 43], a potent negative regulator of HbF expression. It also associated with an increase in HbF levels in beta-thalassaemia patients and upon hydroxyurea treatment in sickle cell anaemia patients. MIR16-1 plays a role in γ-globin gene regulation leading to HbF induction. Therapeutic approaches that increase the HbF concentration have great potential for ameliorating the clinical and haematologic severity of beta-thalassaemia and other beta-haemoglobinopathies.

Synonyms: MIRN16-1 , mir-16-1 , miRNA16-1

Comments:
N/A

Number of entries/variants: 0

1. Sankaran VG, Menne TF, Šćepanović D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF, MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13., Proc Natl Acad Sci U S A, 108(4), 1519-24, 2011 PubMed
2. Eltaweel NH, ElKamah GY, Khairat R, Atia HAE, Amr KS, Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia., J Genet Eng Biotechnol, 19(1), 51, 2021 PubMed
3. Kargutkar N, Sawant-Mulay M, Hariharan P, Chandrakala S, Nadkarni A, Role of microRNA in hydroxyurea mediated HbF induction in sickle cell anaemia patients., Sci Rep, 13(1), 369, 2023 PubMed