GeneID: 467
Names
Common Name: | NFE2 | Type: | Gene |
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Chromosome: | 12 (NC_000012.12) | Locus: | NM_001136023.3 (NFE2 ) |
HUGO Symbol: | NFE2 | Full Name: | Nuclear Factor, Erythroid 2 |
Exons: | 3 | Introns: | 2 |
Description:
NF-E2 is a transcription factor that binds to the β-globin locus control region (LCR) hypersensitive site 2 (HS2) and with the β-globin gene promoter. It is a is a heterodimer composed of the haematopoietic specific subunit p45 and a ubiquitously expressed subunit p18 (small Maf protein). It plays a critical role in the regulation of erythroid and megakaryocytic maturation and differentiation. May play a role in all aspects of haemoglobin production from globin and heme synthesis to procurement of iron.
Synonyms: NF-E2
Comments:
N/A
Number of entries/variants: 0
Sequence Viewer
Publications / Origin
- Woon Kim Y, Kim S, Geun Kim C, Kim A, The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes., Nucleic Acids Res, 39(16), 6944-55, 2011 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2022-01-04 17:31:56 | The IthaGenes Curation Team | Created |