GeneID: 475


Common Name: miR-199a-5p Type: Gene
Chromosome: 19 (NC_000019.10) Locus: NR_029586.1 (MIR199A1)
HUGO Symbol: MIR199A1 Full Name: microRNA 199a-1
Exons: N/A Introns: N/A

MicroRNAs (miRNAs), such as MIR199A1, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. The miR-199a-5p sequence is a product of MIR199A1. miR-199a-5p has been associated with NO metabolism. Its expression was increased in sickle cell disease (SCD) patients with leg ulcers, and associated with hemolytic biomarkers (e.g., NO metabolites, LDH, AST, GGT, iron and ferritin), in addition to an impaired clinical profile of sickle leg ulcers. miR-199a-5p may be part of the genetic background responsible for hemolytic pathophysiology in the occurrence and clinical evolution of sickle cell ulcers.

Synonyms: MIR-199-s , MIRN199A1 , mir-199a-1


Number of entries/variants: 0

External Links


Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Santos EDC, Melo GIV, Santana PVB, Quadros IGS, Yahouédéhou SCMA, Guarda CCD, Santiago RP, Fiuza LM, Carvalho SP, Adorno EV, Kaneto CM, Fonseca TCC, Goncalves MS, Aleluia MM, A Description of the Hemolytic Component in Sickle Leg Ulcer: The Role of Circulating miR-199a-5p, miR-144, and miR-126., Biomolecules, 12(2), 0, 2022 PubMed
Created on 2022-03-11 20:19:44, Last reviewed on (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.