GeneID: 476

Description:
MicroRNAs (miRNAs), such as MIR144, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. It is involved in the regulation of human erythropoiesis by targeting the RAB14 GTPase, a component of the endosomal recycling pathway. It contributes to a severe anemia phenotype in sickle cell disease (SCD) via downregulation of the NRF2 gene [GeneID: 243] and subsequent reduction of oxidative stress tolerance in SCD erythrocytes. A concomitant reduction in γ-globin gene expression is seen in SCD erythrocytes. It is implicated in the hemolytic mechanism driving the occurence and clinical evolution of sickle leg ulcers.

Synonyms: MIRN144 , mir-144

Comments:
N/A

Number of entries/variants: 0

1. Sangokoya C, Telen MJ, Chi JT, microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease., Blood, 116(20), 4338-48, 2010 PubMed
2. Li B, Zhu X, Ward CM, Starlard-Davenport A, Takezaki M, Berry A, Ward A, Wilder C, Neunert C, Kutlar A, Pace BS, MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease., Exp. Hematol., 70(0), 85-96.e5, 2019 PubMed
3. Santos EDC, Melo GIV, Santana PVB, Quadros IGS, Yahouédéhou SCMA, Guarda CCD, Santiago RP, Fiuza LM, Carvalho SP, Adorno EV, Kaneto CM, Fonseca TCC, Goncalves MS, Aleluia MM, A Description of the Hemolytic Component in Sickle Leg Ulcer: The Role of Circulating miR-199a-5p, miR-144, and miR-126., Biomolecules, 12(2), 0, 2022 PubMed