GeneID: 5
Names
Common Name: | βLCR | Type: | Regulatory Sequence |
---|---|---|---|
Chromosome: | 11 (NC_000011.10) | Locus: | NG_000007.3 (β-locus) |
HUGO Symbol: | LCRB | Full Name: | locus control region, beta |
Exons: | N/A | Introns: | N/A |
Description:
The haemoglobin beta (β) locus control region (LCRB) is thought to organize the entire 60-kb β-globin gene cluster into an active chromatin domain and to regulate the transcription of individual globin genes throughout development. The globin genes are arranged as 5'-ε(HBE)-Gγ(HBG2)-Aγ(HBG1)-ψβ(HBBP1)-δ(HBD)-β(HBB)-3' on the β-globin locus. The arrangement of the genes reflects the temporal differentiation of their expression during development, with the early-embryonic stage version of the gene located closest to the LCRB. If the genes are rearranged on the locus, the globin gene products are expressed at improper stages of development.
Synonyms: LCRB
Comments:
N/A
Number of entries/variants: 48
IthaScore
Sequence Viewer
Publications / Origin
- Levings PP, Bungert J, The human beta-globin locus control region., Eur. J. Biochem. , 269(6), 1589-99, 2002 PubMed
- Sawado T, Halow J, Bender MA, Groudine M, The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation., Genes Dev. , 17(8), 1009-18, 2003 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2014-04-01 14:19:10 | The IthaGenes Curation Team | Created |
2 | 2014-04-11 16:18:13 | The IthaGenes Curation Team | Reviewed. Description, synonyms, references and links added. |
3 | 2016-04-28 10:23:41 | The IthaGenes Curation Team | Reviewed. |
4 | 2016-04-28 10:24:28 | The IthaGenes Curation Team | Reviewed. |
5 | 2016-04-28 11:36:12 | The IthaGenes Curation Team | Reviewed. |