GeneID: 67


Common Name: ALOX5AP Type: Gene
Chromosome: 13 (NC_000013.11) Locus: NG_011963.2 (ALOX5AP)
HUGO Symbol: ALOX5AP Full Name: arachidonate 5-lipoxygenase activating protein
Exons: 5 Introns: 4

The encoded protein plays a key role in the production of leukotrienes, peptide-conjugated lipids involved in inflammatory responses. Leukotrienes are generated from arachidonic acid (AA), a polyunsaturated fatty acid bound to the phospholipids of the cell membranes, in several different types of inflammatory cells. When cells are activated, AA is released by cytosolic phospholipase A2 and bound to an integral protein within the nuclear membrane called ALOX5AP. Inactive 5-lipoxygenase (ALOX5) translocates onto the membrane, where it anchors to ALOX5AP. In this complex, ALOX5 becomes activated and catalyses the conversion of AA to 5-hydroperoxy-eicosatetraenoic acid (5-HPETE) and subsequently to an unstable intermediate (LTA4) of the leukotriene pathway. Leukotrienes have been implicated in various types of inflammatory responses, including asthma, allergic rhinitis, arthritis and psoriasis. Polymorphisms in the ALOX5AP gene associated with levels of HbF in sickle cell patients. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Synonyms: FLAP


Sequence Viewer

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Publications / Origin

  1. Dixon RA, Diehl RE, Opas E, Rands E, Vickers PJ, Evans JF, Gillard JW, Miller DK, Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis., Nature , 343(6255), 282-4, 1990 PubMed
  2. Mancini JA, Abramovitz M, Cox ME, Wong E, Charleson S, Perrier H, Wang Z, Prasit P, Vickers PJ, 5-lipoxygenase-activating protein is an arachidonate binding protein., FEBS Lett. , 318(3), 277-81, 1993 PubMed
  3. Sebastiani P, Wang L, Nolan VG, Melista E, Ma Q, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations., Am. J. Hematol. , 83(3), 189-95, 2008 PubMed
Created on 2016-04-26 12:19:41, Last reviewed on 2016-04-26 18:20:08 (Show full history)

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