GeneID: 8

Names

Common Name:	Gγ	Type:	Gene
Chromosome:	11 (NC_000011.10)	Locus:	NG_000007.3 (β-locus)
HUGO Symbol:	HBG2	Full Name:	hemoglobin subunit gamma 2
Exons:	3	Introns:	2

Description:
The γ-globin genes (HBG1 and HBG2) are active during fetal growth and are normally expressed in the fetal liver, spleen and bone marrow. The combination of two γ-globin chains and two α-globin chains forms fetal haemoglobin (HbF; α2γ2). HbF is normally replaced by adult haemoglobin (HbA) at birth. The HBG genes are the result of a 5 kb tandem duplication and differ at position 136 of the HBG chain to encode glutamic acid (Gγ; HBG2) or alanine (Aγ; HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-ε(HBE)-Gγ(HBG2)-Aγ(HBG1)-ψβ(HBBP1)-δ(HBD)-β(HBB)-3'.

Synonyms: HBG-T1

Comments:
N/A

Number of entries/variants: 143

External Links

NCBI Gene	UniProtKB
PDB	HGNC
OMIM

IthaScore

Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

Slightom JL, Blechl AE, Smithies O, Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes., Cell , 21(3), 627-38, 1980 PubMed

Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 10:44:31 (Show full history)

A/A	Date	Curator(s)	Comments
1	2014-04-01 14:19:10	The IthaGenes Curation Team	Created
2	2014-04-09 18:29:45	The IthaGenes Curation Team	Reviewed.
3	2016-04-28 10:44:31	The IthaGenes Curation Team	Reviewed.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.