GeneID: 2
Names
| Common Name: | ζ | Type: | Gene |
|---|---|---|---|
| Chromosome: | 16 (NC_000016.10) | Locus: | NG_000006.1 (α-locus) |
| HUGO Symbol: | HBZ | Full Name: | haemoglobin subunit zeta |
| Exons: | 3 | Introns: | 2 |
Description:
Zeta (ζ)-globin is an alpha (α)-like haemoglobin. The ζ-globin polypeptide is synthesized in the yolk sac of the early embryo, while α-globin is produced throughout fetal and adult life. The ζ-globin gene is a member of the human α-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes on the α-globin locus is: 5’-HBZ2-ΨHBZ1-ΨHBA2-ΨHBA1-HBA2-HBA1-θ-3’. The combination of two ζ chains and two epsilon (ε) chains forms the early embryonic haemoglobin Gower-1, and two ζ chains and two gamma (γ) chains forms the fetal haemoglobin Portland-1. A heterotetramer of two ζ chains and two beta (β) chains forms the haemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassaemia.
Synonyms: Zeta-globin , HBAZ , HBZ2 ,
Comments:
N/A
Number of entries/variants: 92
Sequence Viewer
Publications / Origin
- Cohen-Solal MM, Authier B, deRiel JK, Murnane MJ, Forget BG, Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA., DNA , 1(4), 355-63, 1982 PubMed
- Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ, A review of the molecular genetics of the human alpha-globin gene cluster., Blood , 73(5), 1081-104, 1989 PubMed