GeneID: 2


Common Name: ζ Type: Gene
Chromosome: 16 (NC_000016.10) Locus: NG_000006.1 (α-locus)
HUGO Symbol: HBZ Full Name: haemoglobin subunit zeta
Exons: 3 Introns: 2

Zeta (ζ)-globin is an alpha (α)-like haemoglobin. The ζ-globin polypeptide is synthesized in the yolk sac of the early embryo, while α-globin is produced throughout fetal and adult life. The ζ-globin gene is a member of the human α-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes on the α-globin locus is: 5’-HBZ2-ΨHBZ1-ΨHBA2-ΨHBA1-HBA2-HBA1-θ-3’. The combination of two ζ chains and two epsilon (ε) chains forms the early embryonic haemoglobin Gower-1, and two ζ chains and two gamma (γ) chains forms the fetal haemoglobin Portland-1. A heterotetramer of two ζ chains and two beta (β) chains forms the haemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassaemia.

Synonyms: Zeta-globin , HBAZ , HBZ2 ,


Number of entries/variants: 90


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Publications / Origin

  1. Cohen-Solal MM, Authier B, deRiel JK, Murnane MJ, Forget BG, Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA., DNA , 1(4), 355-63, 1982 PubMed
  2. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ, A review of the molecular genetics of the human alpha-globin gene cluster., Blood , 73(5), 1081-104, 1989 PubMed
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 11:20:50 (Show full history)

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