GeneID: 324


Common Name: MIR155 Type: Gene
Chromosome: 21 (NC_000021.9) Locus: NR_030784.1 (MIR155)
HUGO Symbol: MIR155 Full Name: microRNA 155
Exons: 1 Introns: N/A

MicroRNAs (miRNAs) are small (~22 nt) non-coding RNAs involved in post-transcriptional regulation of gene expression by targeting mRNAs for cleavage or translational repression. miRNAs are transcribed by RNA polymerase II as long primary miRNA transcripts (pri-miRNA), which are sequentially cropped by two ribonuclease III (RNase III) enzymes, Drosha and Dicer. The resulting mature miRNA is then loaded into the RNA induced silencing complex (RISC) where it directs the complex to target mRNAs. The miRNA pathway plays an essential role in the development and/or function of most tissues in the body. Upregulation of miR-155 has been shown to enhance the phagocytic activity of β‑thalassemia/HbE monocytes and mediate the clearance or destruction of abnormal red blood cells, possibly via regulation of its target BACH-1 that is involved in phagocytic function.

Synonyms: MIRN155 , hsa-mir-155


External Links

Sequence Viewer

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Publications / Origin

  1. Hammond SM, An overview of microRNAs., Adv. Drug Deliv. Rev., 87(0), 3-14, 2015 PubMed
  2. Hasan KN, Sufian A, Mazumder AK, Khaleque MA, Rahman M, Akhteruzzaman S, A Novel Pathogenic β-Thalassemia Mutation Identified at Codon 8 (: c.27delG) in a Bangladeshi Family Acquired ., Hemoglobin, 43(3), 162-165, 2019 PubMed
Created on 2019-12-05 11:25:06, Last reviewed on (Show full history)

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