GeneID: 447
Names
| Common Name: | PRDX1 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 1 (NC_000001.11) | Locus: | NM_181697.3 (PRDX1) |
| HUGO Symbol: | PRDX1 | Full Name: | peroxiredoxin 1 |
| Exons: | 6 | Introns: | 5 |
Description:
The PRDX1 gene encodes a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize hydrogen peroxide (H2O2) and act as a molecular chaperone, respectively. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. PRDX1 gene expression and protein levels were found to be elevated in the reticulocytes and erythrocytes of β-thalassaemia intermedia patients compared to healthy controls. Possible role in protecting red cells from oxidative damage.
Synonyms: PAG , PAGA , PAGB , PRX1 , PRXI , MSP23 , NKEFA , TDPX2 , NKEF-A
Comments:
N/A
Number of entries/variants: 0
Sequence Viewer
Publications / Origin
- Zakaria NA, Islam MA, Abdullah WZ, Bahar R, Mohamed Yusoff AA, Abdul Wahab R, Shamsuddin S, Johan MF, Epigenetic Insights and Potential Modifiers as Therapeutic Targets in -Thalassemia., Biomolecules, 11(5), 0, 2021 PubMed