GeneID: 6


Common Name: ε Type: Gene
Chromosome: 11 (NC_000011.10) Locus: NG_000007.3 (β-locus)
HUGO Symbol: HBE1 Full Name: hemoglobin subunit epsilon 1
Exons: 3 Introns: 2

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic haemoglobin Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic haemoglobins are normally supplanted by fetal, and later, adult haemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-ε(HBE)-Gγ(HBG2)-Aγ(HBG1)-ψβ(HBBP1)-δ(HBD)-β(HBB)-3'.

Synonyms: HBE , Epsilon-globin


Number of entries/variants: 43


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Publications / Origin

  1. Gale RE, Clegg JB, Huehns ER, Human embryonic haemoglobins Gower 1 and Gower 2., Nature , 280(5718), 162-4, 1979 PubMed
  2. Baralle FE, Shoulders CC, Proudfoot NJ, The primary structure of the human epsilon-globin gene., Cell , 21(3), 621-6, 1980 PubMed
  3. Fritsch EF, Lawn RM, Maniatis T, Molecular cloning and characterization of the human beta-like globin gene cluster., Cell , 19(4), 959-72, 1980 PubMed
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 11:35:00 (Show full history)

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